Phosphorylation Regulates FOXC2-Mediated Transcription in Lymphatic Endothelial Cells
Identifieur interne : 003300 ( Main/Exploration ); précédent : 003299; suivant : 003301Phosphorylation Regulates FOXC2-Mediated Transcription in Lymphatic Endothelial Cells
Auteurs : Konstantin I. Ivanov ; Yan Agalarov ; Leena Valmu ; Olga Samuilova ; Johanna Liebl ; Nawal Houhou ; Hélène Maby-El Hajjami ; Camilla Norrmén ; Muriel Jaquet ; Naoyuki Miura ; Nadine Zangger ; Seppo Yl Herttuala ; Mauro Delorenzi ; Tatiana V. PetrovaSource :
- Molecular and Cellular Biology [ 0270-7306 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Cellules COS, Cellules HEK293, Cellules HepG2, Cellules cultivées, Cellules endothéliales (métabolisme), Cercopithecus aethiops, Données de séquences moléculaires, Facteurs de transcription Forkhead (génétique), Facteurs de transcription Forkhead (métabolisme), Humains, Immunotransfert, Microscopie confocale, Mutation, Phosphorylation, Proline (génétique), Proline (métabolisme), RT-PCR, Régulation de l'expression des gènes, Sites de fixation (génétique), Souris, Souris transgéniques, Séquence d'acides aminés, Séquençage par oligonucléotides en batterie, Sérine (génétique), Sérine (métabolisme), Thréonine (génétique), Thréonine (métabolisme), Transcription génétique (génétique).
- MESH :
- génétique : Facteurs de transcription Forkhead, Proline, Sites de fixation, Sérine, Thréonine, Transcription génétique.
- métabolisme : Cellules endothéliales, Facteurs de transcription Forkhead, Proline, Sérine, Thréonine.
- Animaux, Cellules COS, Cellules HEK293, Cellules HepG2, Cellules cultivées, Cercopithecus aethiops, Données de séquences moléculaires, Humains, Immunotransfert, Microscopie confocale, Mutation, Phosphorylation, RT-PCR, Régulation de l'expression des gènes, Souris, Souris transgéniques, Séquence d'acides aminés, Séquençage par oligonucléotides en batterie.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Binding Sites (genetics), COS Cells, Cells, Cultured, Cercopithecus aethiops, Endothelial Cells (metabolism), Forkhead Transcription Factors (genetics), Forkhead Transcription Factors (metabolism), Gene Expression Regulation, HEK293 Cells, Hep G2 Cells, Humans, Immunoblotting, Mice, Mice, Transgenic, Microscopy, Confocal, Molecular Sequence Data, Mutation, Oligonucleotide Array Sequence Analysis, Phosphorylation, Proline (genetics), Proline (metabolism), Reverse Transcriptase Polymerase Chain Reaction, Serine (genetics), Serine (metabolism), Threonine (genetics), Threonine (metabolism), Transcription, Genetic (genetics).
- MESH :
- chemical , genetics : Forkhead Transcription Factors, Proline, Serine, Threonine.
- genetics : Binding Sites, Transcription, Genetic.
- metabolism : Endothelial Cells, Forkhead Transcription Factors, Proline, Serine, Threonine.
- Amino Acid Sequence, Animals, COS Cells, Cells, Cultured, Cercopithecus aethiops, Gene Expression Regulation, HEK293 Cells, Hep G2 Cells, Humans, Immunoblotting, Mice, Mice, Transgenic, Microscopy, Confocal, Molecular Sequence Data, Mutation, Oligonucleotide Array Sequence Analysis, Phosphorylation, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
One of the key mechanisms linking cell signaling and control of gene expression is reversible phosphorylation of transcription factors. FOXC2 is a forkhead transcription factor that is mutated in the human vascular disease lymphedema-distichiasis and plays an essential role in lymphatic vascular development. However, the mechanisms regulating FOXC2 transcriptional activity are not well understood. We report here that FOXC2 is phosphorylated on eight evolutionarily conserved proline-directed serine/threonine residues. Loss of phosphorylation at these sites triggers substantial changes in the FOXC2 transcriptional program. Through genome-wide location analysis in lymphatic endothelial cells, we demonstrate that the changes are due to selective inhibition of FOXC2 recruitment to chromatin. The extent of the inhibition varied between individual binding sites, suggesting a novel rheostat-like mechanism by which expression of specific genes can be differentially regulated by FOXC2 phosphorylation. Furthermore, unlike the wild-type protein, the phosphorylation-deficient mutant of FOXC2 failed to induce vascular remodeling
Url:
DOI: 10.1128/MCB.01387-12
PubMed: 23878394
PubMed Central: 3811871
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 003087
- to stream Pmc, to step Curation: 003086
- to stream Pmc, to step Checkpoint: 002072
- to stream PubMed, to step Corpus: 001A06
- to stream PubMed, to step Curation: 001A06
- to stream PubMed, to step Checkpoint: 001A06
- to stream Ncbi, to step Merge: 005B66
- to stream Ncbi, to step Curation: 005B66
- to stream Ncbi, to step Checkpoint: 005B66
- to stream Main, to step Merge: 003306
- to stream Main, to step Curation: 003300
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Phosphorylation Regulates FOXC2-Mediated Transcription in Lymphatic Endothelial Cells</title><author><name sortKey="Ivanov, Konstantin I" sort="Ivanov, Konstantin I" uniqKey="Ivanov K" first="Konstantin I." last="Ivanov">Konstantin I. Ivanov</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Agalarov, Yan" sort="Agalarov, Yan" uniqKey="Agalarov Y" first="Yan" last="Agalarov">Yan Agalarov</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Valmu, Leena" sort="Valmu, Leena" uniqKey="Valmu L" first="Leena" last="Valmu">Leena Valmu</name><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Samuilova, Olga" sort="Samuilova, Olga" uniqKey="Samuilova O" first="Olga" last="Samuilova">Olga Samuilova</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Liebl, Johanna" sort="Liebl, Johanna" uniqKey="Liebl J" first="Johanna" last="Liebl">Johanna Liebl</name><affiliation><nlm:aff id="aff5"></nlm:aff></affiliation></author><author><name sortKey="Houhou, Nawal" sort="Houhou, Nawal" uniqKey="Houhou N" first="Nawal" last="Houhou">Nawal Houhou</name><affiliation><nlm:aff id="aff6"></nlm:aff></affiliation></author><author><name sortKey="Maby El Hajjami, Helene" sort="Maby El Hajjami, Helene" uniqKey="Maby El Hajjami H" first="Hélène" last="Maby-El Hajjami">Hélène Maby-El Hajjami</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Norrmen, Camilla" sort="Norrmen, Camilla" uniqKey="Norrmen C" first="Camilla" last="Norrmén">Camilla Norrmén</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Jaquet, Muriel" sort="Jaquet, Muriel" uniqKey="Jaquet M" first="Muriel" last="Jaquet">Muriel Jaquet</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Miura, Naoyuki" sort="Miura, Naoyuki" uniqKey="Miura N" first="Naoyuki" last="Miura">Naoyuki Miura</name><affiliation><nlm:aff id="aff7"></nlm:aff></affiliation></author><author><name sortKey="Zangger, Nadine" sort="Zangger, Nadine" uniqKey="Zangger N" first="Nadine" last="Zangger">Nadine Zangger</name><affiliation><nlm:aff id="aff6"></nlm:aff></affiliation></author><author><name sortKey="Yl Herttuala, Seppo" sort="Yl Herttuala, Seppo" uniqKey="Yl Herttuala S" first="Seppo" last="Yl Herttuala">Seppo Yl Herttuala</name><affiliation><nlm:aff id="aff8"></nlm:aff></affiliation></author><author><name sortKey="Delorenzi, Mauro" sort="Delorenzi, Mauro" uniqKey="Delorenzi M" first="Mauro" last="Delorenzi">Mauro Delorenzi</name><affiliation><nlm:aff id="aff6"></nlm:aff></affiliation><affiliation><nlm:aff id="aff10"></nlm:aff></affiliation><affiliation><nlm:aff id="aff11"></nlm:aff></affiliation></author><author><name sortKey="Petrova, Tatiana V" sort="Petrova, Tatiana V" uniqKey="Petrova T" first="Tatiana V." last="Petrova">Tatiana V. Petrova</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation><affiliation><nlm:aff id="aff9"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23878394</idno><idno type="pmc">3811871</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811871</idno><idno type="RBID">PMC:3811871</idno><idno type="doi">10.1128/MCB.01387-12</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">003087</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003087</idno><idno type="wicri:Area/Pmc/Curation">003086</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003086</idno><idno type="wicri:Area/Pmc/Checkpoint">002072</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002072</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001A06</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001A06</idno><idno type="wicri:Area/PubMed/Curation">001A06</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001A06</idno><idno type="wicri:Area/PubMed/Checkpoint">001A06</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001A06</idno><idno type="wicri:Area/Ncbi/Merge">005B66</idno><idno type="wicri:Area/Ncbi/Curation">005B66</idno><idno type="wicri:Area/Ncbi/Checkpoint">005B66</idno><idno type="wicri:doubleKey">0270-7306:2013:Ivanov K:phosphorylation:regulates:foxc</idno><idno type="wicri:Area/Main/Merge">003306</idno><idno type="wicri:Area/Main/Curation">003300</idno><idno type="wicri:Area/Main/Exploration">003300</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Phosphorylation Regulates FOXC2-Mediated Transcription in Lymphatic Endothelial Cells</title><author><name sortKey="Ivanov, Konstantin I" sort="Ivanov, Konstantin I" uniqKey="Ivanov K" first="Konstantin I." last="Ivanov">Konstantin I. Ivanov</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Agalarov, Yan" sort="Agalarov, Yan" uniqKey="Agalarov Y" first="Yan" last="Agalarov">Yan Agalarov</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Valmu, Leena" sort="Valmu, Leena" uniqKey="Valmu L" first="Leena" last="Valmu">Leena Valmu</name><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Samuilova, Olga" sort="Samuilova, Olga" uniqKey="Samuilova O" first="Olga" last="Samuilova">Olga Samuilova</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Liebl, Johanna" sort="Liebl, Johanna" uniqKey="Liebl J" first="Johanna" last="Liebl">Johanna Liebl</name><affiliation><nlm:aff id="aff5"></nlm:aff></affiliation></author><author><name sortKey="Houhou, Nawal" sort="Houhou, Nawal" uniqKey="Houhou N" first="Nawal" last="Houhou">Nawal Houhou</name><affiliation><nlm:aff id="aff6"></nlm:aff></affiliation></author><author><name sortKey="Maby El Hajjami, Helene" sort="Maby El Hajjami, Helene" uniqKey="Maby El Hajjami H" first="Hélène" last="Maby-El Hajjami">Hélène Maby-El Hajjami</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Norrmen, Camilla" sort="Norrmen, Camilla" uniqKey="Norrmen C" first="Camilla" last="Norrmén">Camilla Norrmén</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Jaquet, Muriel" sort="Jaquet, Muriel" uniqKey="Jaquet M" first="Muriel" last="Jaquet">Muriel Jaquet</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Miura, Naoyuki" sort="Miura, Naoyuki" uniqKey="Miura N" first="Naoyuki" last="Miura">Naoyuki Miura</name><affiliation><nlm:aff id="aff7"></nlm:aff></affiliation></author><author><name sortKey="Zangger, Nadine" sort="Zangger, Nadine" uniqKey="Zangger N" first="Nadine" last="Zangger">Nadine Zangger</name><affiliation><nlm:aff id="aff6"></nlm:aff></affiliation></author><author><name sortKey="Yl Herttuala, Seppo" sort="Yl Herttuala, Seppo" uniqKey="Yl Herttuala S" first="Seppo" last="Yl Herttuala">Seppo Yl Herttuala</name><affiliation><nlm:aff id="aff8"></nlm:aff></affiliation></author><author><name sortKey="Delorenzi, Mauro" sort="Delorenzi, Mauro" uniqKey="Delorenzi M" first="Mauro" last="Delorenzi">Mauro Delorenzi</name><affiliation><nlm:aff id="aff6"></nlm:aff></affiliation><affiliation><nlm:aff id="aff10"></nlm:aff></affiliation><affiliation><nlm:aff id="aff11"></nlm:aff></affiliation></author><author><name sortKey="Petrova, Tatiana V" sort="Petrova, Tatiana V" uniqKey="Petrova T" first="Tatiana V." last="Petrova">Tatiana V. Petrova</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation><affiliation><nlm:aff id="aff9"></nlm:aff></affiliation></author></analytic><series><title level="j">Molecular and Cellular Biology</title><idno type="ISSN">0270-7306</idno><idno type="eISSN">1098-5549</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Binding Sites (genetics)</term><term>COS Cells</term><term>Cells, Cultured</term><term>Cercopithecus aethiops</term><term>Endothelial Cells (metabolism)</term><term>Forkhead Transcription Factors (genetics)</term><term>Forkhead Transcription Factors (metabolism)</term><term>Gene Expression Regulation</term><term>HEK293 Cells</term><term>Hep G2 Cells</term><term>Humans</term><term>Immunoblotting</term><term>Mice</term><term>Mice, Transgenic</term><term>Microscopy, Confocal</term><term>Molecular Sequence Data</term><term>Mutation</term><term>Oligonucleotide Array Sequence Analysis</term><term>Phosphorylation</term><term>Proline (genetics)</term><term>Proline (metabolism)</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Serine (genetics)</term><term>Serine (metabolism)</term><term>Threonine (genetics)</term><term>Threonine (metabolism)</term><term>Transcription, Genetic (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules COS</term><term>Cellules HEK293</term><term>Cellules HepG2</term><term>Cellules cultivées</term><term>Cellules endothéliales (métabolisme)</term><term>Cercopithecus aethiops</term><term>Données de séquences moléculaires</term><term>Facteurs de transcription Forkhead (génétique)</term><term>Facteurs de transcription Forkhead (métabolisme)</term><term>Humains</term><term>Immunotransfert</term><term>Microscopie confocale</term><term>Mutation</term><term>Phosphorylation</term><term>Proline (génétique)</term><term>Proline (métabolisme)</term><term>RT-PCR</term><term>Régulation de l'expression des gènes</term><term>Sites de fixation (génétique)</term><term>Souris</term><term>Souris transgéniques</term><term>Séquence d'acides aminés</term><term>Séquençage par oligonucléotides en batterie</term><term>Sérine (génétique)</term><term>Sérine (métabolisme)</term><term>Thréonine (génétique)</term><term>Thréonine (métabolisme)</term><term>Transcription génétique (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Forkhead Transcription Factors</term><term>Proline</term><term>Serine</term><term>Threonine</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Binding Sites</term><term>Transcription, Genetic</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteurs de transcription Forkhead</term><term>Proline</term><term>Sites de fixation</term><term>Sérine</term><term>Thréonine</term><term>Transcription génétique</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Endothelial Cells</term><term>Forkhead Transcription Factors</term><term>Proline</term><term>Serine</term><term>Threonine</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cellules endothéliales</term><term>Facteurs de transcription Forkhead</term><term>Proline</term><term>Sérine</term><term>Thréonine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>COS Cells</term><term>Cells, Cultured</term><term>Cercopithecus aethiops</term><term>Gene Expression Regulation</term><term>HEK293 Cells</term><term>Hep G2 Cells</term><term>Humans</term><term>Immunoblotting</term><term>Mice</term><term>Mice, Transgenic</term><term>Microscopy, Confocal</term><term>Molecular Sequence Data</term><term>Mutation</term><term>Oligonucleotide Array Sequence Analysis</term><term>Phosphorylation</term><term>Reverse Transcriptase Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules COS</term><term>Cellules HEK293</term><term>Cellules HepG2</term><term>Cellules cultivées</term><term>Cercopithecus aethiops</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Immunotransfert</term><term>Microscopie confocale</term><term>Mutation</term><term>Phosphorylation</term><term>RT-PCR</term><term>Régulation de l'expression des gènes</term><term>Souris</term><term>Souris transgéniques</term><term>Séquence d'acides aminés</term><term>Séquençage par oligonucléotides en batterie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>One of the key mechanisms linking cell signaling and control of gene expression is reversible phosphorylation of transcription factors. FOXC2 is a forkhead transcription factor that is mutated in the human vascular disease lymphedema-distichiasis and plays an essential role in lymphatic vascular development. However, the mechanisms regulating FOXC2 transcriptional activity are not well understood. We report here that FOXC2 is phosphorylated on eight evolutionarily conserved proline-directed serine/threonine residues. Loss of phosphorylation at these sites triggers substantial changes in the FOXC2 transcriptional program. Through genome-wide location analysis in lymphatic endothelial cells, we demonstrate that the changes are due to selective inhibition of FOXC2 recruitment to chromatin. The extent of the inhibition varied between individual binding sites, suggesting a novel rheostat-like mechanism by which expression of specific genes can be differentially regulated by FOXC2 phosphorylation. Furthermore, unlike the wild-type protein, the phosphorylation-deficient mutant of FOXC2 failed to induce vascular remodeling <italic>in vivo</italic>. Collectively, our results point to the pivotal role of phosphorylation in the regulation of FOXC2-mediated transcription in lymphatic endothelial cells and underscore the importance of FOXC2 phosphorylation in vascular development.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Agalarov, Yan" sort="Agalarov, Yan" uniqKey="Agalarov Y" first="Yan" last="Agalarov">Yan Agalarov</name><name sortKey="Delorenzi, Mauro" sort="Delorenzi, Mauro" uniqKey="Delorenzi M" first="Mauro" last="Delorenzi">Mauro Delorenzi</name><name sortKey="Houhou, Nawal" sort="Houhou, Nawal" uniqKey="Houhou N" first="Nawal" last="Houhou">Nawal Houhou</name><name sortKey="Ivanov, Konstantin I" sort="Ivanov, Konstantin I" uniqKey="Ivanov K" first="Konstantin I." last="Ivanov">Konstantin I. Ivanov</name><name sortKey="Jaquet, Muriel" sort="Jaquet, Muriel" uniqKey="Jaquet M" first="Muriel" last="Jaquet">Muriel Jaquet</name><name sortKey="Liebl, Johanna" sort="Liebl, Johanna" uniqKey="Liebl J" first="Johanna" last="Liebl">Johanna Liebl</name><name sortKey="Maby El Hajjami, Helene" sort="Maby El Hajjami, Helene" uniqKey="Maby El Hajjami H" first="Hélène" last="Maby-El Hajjami">Hélène Maby-El Hajjami</name><name sortKey="Miura, Naoyuki" sort="Miura, Naoyuki" uniqKey="Miura N" first="Naoyuki" last="Miura">Naoyuki Miura</name><name sortKey="Norrmen, Camilla" sort="Norrmen, Camilla" uniqKey="Norrmen C" first="Camilla" last="Norrmén">Camilla Norrmén</name><name sortKey="Petrova, Tatiana V" sort="Petrova, Tatiana V" uniqKey="Petrova T" first="Tatiana V." last="Petrova">Tatiana V. Petrova</name><name sortKey="Samuilova, Olga" sort="Samuilova, Olga" uniqKey="Samuilova O" first="Olga" last="Samuilova">Olga Samuilova</name><name sortKey="Valmu, Leena" sort="Valmu, Leena" uniqKey="Valmu L" first="Leena" last="Valmu">Leena Valmu</name><name sortKey="Yl Herttuala, Seppo" sort="Yl Herttuala, Seppo" uniqKey="Yl Herttuala S" first="Seppo" last="Yl Herttuala">Seppo Yl Herttuala</name><name sortKey="Zangger, Nadine" sort="Zangger, Nadine" uniqKey="Zangger N" first="Nadine" last="Zangger">Nadine Zangger</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003300 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003300 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3811871
|texte= Phosphorylation Regulates FOXC2-Mediated Transcription in Lymphatic Endothelial Cells
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23878394" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |